Articles: Recent submissions
Now showing items 1-20 of 27
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Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats
(ISME, 2022)Bamboo rats (Rhizomys pruinosus) are among the few mammals that lives on a bamboo-based diet which is mainly composed of lignocellulose. However, the mechanisms of adaptation of their gut microbiome and metabolic systems ... -
Structural Insight into the Binding of Cyanovirin-N with the Spike Glycoprotein, Mpro and PLpro of SARS-CoV-2: Protein–Protein Interactions, Dynamics Simulations and Free Energy Calculations
(MPDI, 2021)The emergence of COVID-19 continues to pose severe threats to global public health. The pandemic has infected over 171 million people and claimed more than 3.5 million lives to date. We investigated the binding potential ... -
Host Adaptive Evolution of Avian-Origin H3N2 Canine Influenza Virus
(frontiers in Micrology, 2021)Since its first isolation in around 2007, the avian-origin H3N2 canine influenza virus (CIV) has become established and continues to circulate in dog populations. This virus serves as a useful model for deciphering the ... -
Synthesis of Carvacrol Derivatives as Potential New Anticancer Agent against Lung Cancer
(MDPI, 2022)Lung cancer remains a major public health concern among all cancer diseases due to the toxicity and side-effects of the available commercially synthesized drugs. Natural product-derived synthesized anticancer drugs are ... -
Computational profiling of natural compounds as promising inhibitors against the spike proteins of SARS‐CoV‐2 wild‐type and the variants of concern, viral cell‐entry process, and cytokine storm in COVID‐19
(Wiley Periodicals LLC, 2022)The continuous spread and evolution of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), and the rapid surge in infection cases in the coronavirus disease 2019 (COVID‐19) evoke a dire need for ... -
Hen raising helps chicks establish gut microbiota in their early life and improve microbiota stability after H9N2 challenge
(Microbiome, 2022)Background: Early gut microbial colonization is important for postnatal growth and immune development of the chicken. However, at present, commercial chickens are hatched and raised without adult hens, thus are cut off from ... -
Computational profiling of natural compounds as promising inhibitors against the spike proteins of SARS‐CoV‐2 wild‐type and the variants of concern, viral cell‐entry process, and cytokine storm in COVID‐19
(Wiley Periodicals LLC, 2022)The continuous spread and evolution of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), and the rapid surge in infection cases in the coronavirus disease 2019 (COVID‐19) evoke a dire need for ... -
Evolutionary perspectives and adaptation dynamics of human seasonal influenza viruses from 2009 to 2019:an insight from codon usage
(ELSEVIER, 2021)The annually recurrent seasonal influenza viruses, namely, influenza A viruses (H1N1/pdm2009 and H3N2) and influenza B viruses, contribute substantially to human disease burden. Elucidation of host adaptation, population ... -
Environmental survival of SARS-CoV-2 – A solid waste perspective
(ELSEVIER, 2021)The advent of COVID-19 has kept the whole world on their toes. Countries are maximizing their efforts to combat the virus and to minimize the infection. Since infectious microorganisms may be transmitted by variety of ... -
Structural Insight into the Binding of Cyanovirin-N with the Spike Glycoprotein, Mpro and PLpro of SARS-CoV-2: Protein–Protein Interactions, Dynamics Simulations and Free Energy Calculations
(MPDI, 2021)The emergence of COVID-19 continues to pose severe threats to global public health. The pandemic has infected over 171 million people and claimed more than 3.5 million lives to date. We investigated the binding potential ... -
Elucidation of phytomedicinal efficacies of Clerodendrum inerme (L.) Gaertn. (Wild Jasmine)
(ELSEVIER, 2020)Clerodendrum inerme is a perennial shrub belonging to the family Lamiaceae and is used in many of the herbal preparations of Siddha and Ayurveda in India. Ethnomedicinally, the leaves of this plant are used to cure ... -
Anisotine and amarogentin as promising inhibitory candidates against SARS-CoV-2 proteins: a computational investigation
(Taylor & Francis, 2020-09)The coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syn- drome coronavirus 2 (SARS-CoV-2), presents an unprecedented challenge to global public health with researchers striving ... -
Natural compounds from Clerodendrum spp. as possible therapeutic candidates against SARS-CoV-2: An in silico investigation
(Taylor & Francis, 2020-05)The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has rattled global public health, with researchers struggling to find specific therapeutic solutions. In this context, the present study employed an in ... -
Host Adaptation and Evolutionary Analysis of Zaire ebolavirus: Insights From Codon Usage Based Investigations
(frontiers in Micrology, 2020)Ebola virus (EBOV) has caused several outbreaks as the consequence of spillover events from zoonotic sources and has resulted in huge death tolls. In spite of considerable progress, a thorough know-how regarding EBOV ... -
Oxidative stress and mitochondrial transfer: A new dimension towards ocular diseases
(ELSEVIER, 2020)Ocular cells like, retinal pigment epithelium (RPE) is a highly specialized pigmented monolayer of post-mitotic cells, which is located in the posterior segment of the eye between neuro sensory retina and vascular choroid. ... -
Codon usage signatures in the genus Cryptococcus: A complex interplay of gene expression, translational selection and compositional bias
(ELSEVIER, 2020)The fungal genus Cryptococcus comprises of several diverse species. The pathogens forming Cryptococcus neo- formans/ Cryptococcus gatti species complex are of immense clinical significance owing to the high frequency ... -
Cyanobacterial metabolites as promising drug leads against the Mpro and PLpro of SARS-CoV-2: an in silico analysis
(Taylor & Francis, 2020)A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged as the causative agent behind the coronavirus disease 2019 (COVID-19) pandemic. Treatment efforts have been severely impeded due to the ... -
Insights into the riddles of codon usage patterns and codon context signatures in fungal genus Puccinia, a persistent threat to global agriculture
(2018)The fungal genus Puccinia, comprising of several menacing pathogens, has been a persistent peril to global agriculture. Genome sequencing of various members of Puccinia offers a scope to excavate their genomic riddles. ... -
Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities
(CrossMark, 2018)The present study has been aimed to the com- parative analysis of high GC composition containing Corynebacterium genomes and their evolutionary study by exploring codon and amino acid usage patterns. Phyloge- netic ... -
Comparative genomics of Mycobacterium reveals evolutionary trends of M. avium complex
(ELSEVIER, 2018)Mycobacterium is gram positive, slow growing, disease causing Actinobacteria. Beside potential pathogenic spe- cies, Mycobacterium also contains opportunistic pathogens as well as free living non-pathogenic species. ...