https://repository.auw.edu.bd/handle/123456789/784 Wed, 13 May 2026 16:42:00 GMT 2026-05-13T16:42:00Z https://repository.auw.edu.bd/handle/123456789/964 PUBLICATIONS Selvakumar, Mosae Wed, 01 Jan 2025 00:00:00 GMT https://repository.auw.edu.bd/handle/123456789/964 2025-01-01T00:00:00Z https://repository.auw.edu.bd/handle/123456789/963 CV Selvakumar, Paulraj Wed, 01 Jan 2025 00:00:00 GMT https://repository.auw.edu.bd/handle/123456789/963 2025-01-01T00:00:00Z https://repository.auw.edu.bd/handle/123456789/962 Computational Studies on T2Rs Agonist-Based Anti–COVID-19 Drug Design Selvakumar Paulraj, Mosae The expeditious and world pandemic viral disease of new coronavirus (SARS-CoV-2) has formed a prompt urgency to discover auspicious target-based ligand for the treatment of COVID-19. Symptoms of novel coronavirus disease (COVID-19) typically include dry cough, fever, and shortness of breath. Recent studies on many COVID-19 patients in Italy and the United Kingdom found increasing anosmia and ageusia among the COVID- 19-infected patients. SARS-CoV-2 possibly infects neurons in the nasal passage and disrupts the senses of smell and taste, like other coronaviruses, such as SARS-CoV and MERS-CoV that could target the central nervous system. Developing a drug based on the T2Rs might be of better understanding and worth finding better molecules to act against COVID-19. In this research, we have taken a taste receptor agonist molecule to find a better core molecule that may act as the best resource to design a drug or corresponding derivatives. Based on the computational docking studies, the antibiotic tobramycin showed the best interaction against 6LU7 COVID-19 main protease. Aromatic carbonyl functional groups of the molecule established intermolecular hydrogen bonding interaction with GLN189 amino acid and it showed the two strongest carbonyl interactions with receptor protein resulting in a glide score of −11.159. To conclude, depending on the molecular recognition of the GPCR proteins, the agonist molecule can be recognized to represent the cell secondary mechanism; thus, it provides enough confidence to design a suitable molecule based on the tobramycin drug. Fri, 01 Jan 2021 00:00:00 GMT https://repository.auw.edu.bd/handle/123456789/962 2021-01-01T00:00:00Z https://repository.auw.edu.bd/handle/123456789/961 Tuning of Photoluminescence and Antibacterial Properties of ZnO Nanoparticles through Sr Doping for Biomedical Applications Selvakumar Paulraj, Mosae Sr-doped ZnO nanoparticles have been synthesized using a soft chemical method. The doping ratio of Sr is varied in the range of 0 at.%, 3 at.%, and 5 at.% to 7 at.%. X-ray diffractograms revealed that the samples had hexagonal (wurtzite) structure without a trace of any mixed phase. The average crystallite size of the nanoparticles (NPs) ranged from 39 to 46 nm. The average crystallite size was increased for the initial doping (3 at.%) of Sr ions, and further increase in the doping ratio reduced the particle size due to some distortion produced in the lattice. The surface morphology of the samples and structure of the NPs were investigated using FESEM (Field Emission Scanning Electron Microscopy) and TEM (Transmission Electron Microscopy) pictures, respectively. EDX (energy-dispersive X-ray) spectroscopy confirmed the presence of strontium (Sr) in the host lattice. Photoluminescence and X-ray diffraction confirmed that the dopant ions replace some of the lattice zinc ions and that Sr2+ and Sr3+ ions coexist in the ZnO lattice. The Sr-doped ZnO exhibited violet and blue luminescence spectra at 408 nm and 492 nm, respectively. ZnO : Sr nanoparticles showed increased antibacterial activity against one gram-positive as well as one gram-negative bacteria. Fri, 01 Jan 2021 00:00:00 GMT https://repository.auw.edu.bd/handle/123456789/961 2021-01-01T00:00:00Z