Computational profiling of differentially expressed genes & long noncoding RNAs implicated in host immune response and virus proliferation at different time points in Dengue Virus infection

Abstract

lncRNAs, or long non-coding RNAs, have become significant regulators of viral infection and the antiviral response. The purpose of the current study was to examine how the Dengue Virus (DENV) infection affects lncRNAs. The differentially expressed long noncoding RNA genes were discovered by studying a transcriptome dataset of DENV-infected cells at several periods. The research identified 387 downregulated genes and a total of 944 upregulated genes, of which 50 lncRNA genes were downregulated and 39 were upregulated. Seven RNA-binding proteins were discovered to interact with these lncRNA genes, and these proteins are crucial for both viral replication and the host immune response. The findings of this study suggest that in DENV infection, dysregulated lncRNAs play a critical role in viral growth, and immunological response, eventually dictating the course of the disease. The significance of lncRNAs in the setting of viral infection is highlighted by the findings, which may have a substantial impact on the creation of novel treatment approaches for DENV infection. The research adds to the expanding body of knowledge on non-coding RNAs' function in viral pathogenesis and lays the groundwork for future investigations into the specific processes driving lncRNA-mediated control of dengue virus infection.