A Database for Mycobacterium Secretome Analysis: ‘MycoSec’ to Accelerate Global Health Research

Abstract

Members of the genus Mycobacterium are notorious for their pathogenesis. Investigations from various per- spectives have identified the pathogenic strategies employed by these lethal pathogens. Secretomes are believed

to play crucial roles in host cell recognition and cross-talks, in cellular attachment, and in triggering other functions related to host pathogen interactions. However, a proper idea of the mycobacterial secretomes and their mechanism of functionality still remains elusive. In the present study, we have developed a comprehensive

database of potential mycobacterial secretomes (MycoSec) using pre-existing algorithms for secretome predic- tion for researchers interested in this particular field. The database provides a platform for retrieval and analysis

of identified secretomes in all finished genomes of the family Mycobacteriaceae. The database contains valuable information regarding secretory signal peptides (Sec type), lipoprotein signal peptides (Lipo type), and Twin arginine (RR/KR) signal peptides (TAT type), prevalent in mycobacteria. Information pertaining to COG analysis, codon usage, and gene expression of the predicted secretomes has also been incorporated in the

database. MycoSec promises to be a useful repertoire providing a plethora of information regarding myco- bacterial secretomes and may well be a platform to speed global health research. MycoSec is freely accessible at

http://www.bicnbu.in/mycosec.